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COPPER CITRATE
PENTAHYDRATE
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PRODUCT IDENTIFICATION |
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| CAS NO. | 10402-15-0 |
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| EINECS NO. | ||
| FORMULA | Cu3(C6H5O7)2 | |
| MOL WT. | 568.84 | |
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H.S. CODE |
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DERIVATION |
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CLASSIFICATION |
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TOXICITY |
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| SYNONYMS | Citric acid copper salt; Tricupric citrate; | |
| 2-Hydroxy-1,2,3-Propanetricarboxylic acid, copper salt (2:3); | ||
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
blue powder | |
| MELTING POINT | ||
| BOILING POINT |
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| SPECIFIC GRAVITY |
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| SOLUBILITY IN WATER | almost insoluble | |
| pH | 5.6 - 5.8 (5% sol.) | |
| VAPOR DENSITY | practically 0 | |
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AUTOIGNITION |
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NFPA RATINGS |
Health: 1; Flammability: 0; Reactivity: 0 | |
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY | Stable under ordinary conditions | |
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APPLICATIONS |
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| Several lines of evidence have recently suggested that the essential trace metal copper may play a key role in the neuropathologyof neurodegenerative disorders such as prion disease and Alzheimer's disease. The purpose of this review is to evaluate recently published work that implicates copper in neurodegenerative disorders. Several physiological functions of PrPc have been proposed. Cellular prion protein binds Cu2+ through the octapeptide repeat motif located in its N-terminal region, and this interaction appears to induce PrPc internalization, suggesting a role of PrPc in copper metabolism. An antioxidant role for PrPc has also been proposed. In addition, it has been shown that PrPc is susceptible to copper-catalyzed oxidation in the presence of autoxidizable substances, such as L-ascorbate and dopamine. There have also been several results suggesting interactions between PrPSc and copper, and a possible role of this metal in prion disease. First, copper facilitates the restoration of protease resistance and infectivity during the refolding of guanidine-denatured PrPSc. Second, copper binding has been shown to favor the formation of s-sheet structures in PrPC, and to induce fibrillation and aggregation. However, such copper-induced changes in the biochemical properties of PrPC are not sufficient for its conversion into PrPSc. Several recent studies have shown that synthetic A.BETA. and purified APP undergo physicochemical interactions with Zn(II), Cu(II) and Fe(III) with low micromolar and submicromolar concentrations of the metal ions. APP can reduce Cu(II) to Cu(I), which results in oxidation of Cys-144 and Cys-158 yielding intramolecular disulfide bridge. The resulting APP-Cu(I) complex is prone to redox reactions that result in site-specific APP fragmentation (http://sciencelinks.jp) | ||
| SALES SPECIFICATION | ||
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BIBLIOGRAPHY |
BP |
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APPEARANCE |
blue powder |
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| ASSAY |
98.5% min |
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| Cu CONTENT |
34.0 - 38.0% |
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| HEAVY METALS |
20ppm max |
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| CADMIUM (as Cd) |
5ppm max |
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| LEAD (as Pb) |
10ppm max |
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| ARSENIC (as As) |
5ppm max |
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| TRANSPORTATION | ||
| PACKING | | |
| HAZARD CLASS | ||
| UN NO. | ||
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